This web page was produced as an assignment forGenetics 677, an undergraduate course in UW Madison

Official name: GSK3B (glycogen synthase kinase 3 beta) 
Location: Chromosome 3 ;3q13.3
Nucleotide sequence in FASTA format
Protein sequence in FASTA format
Accession number : NM_002093

GSK3-B belongs to the large family of serine-threonine protein kinases. These enzymes phosphorylate their substrates on specific amino acid residues (serine or threonine in this case) leading to their subsequent activation or inhibition. This mechanism makes the protein kinases extremely powerful and versatile regulators in many different biological pathways. It is not surprising that  most structures and functions of the protein kinases are conserved throughout the evolution. GSK3 as a member of this family is not an exception. In order to better understand how the protein evolved throughout the history it will be helpful to observe and compare its organization in different organisms. For this purpose we can use wide variety of developed computational approaches and algorithms created by scientists who work in the bioinfromatic field.  Some these programs are open to the public, easy to use and provide a high degree of statistical analysis. 

Homology

Phylogeny

DNA motifs

Protein domains

Structure and function

Phenotypes

Protein-protein interactions

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 References:

1. National Center of Biotechnology information:http://www.ncbi.nlm.nih.gov

Contact information

This webpage was created by: Eva Dimitrova, [email protected]